This study by IIT bath has shown that excessive sugar intake leads to a fatty heart. It must offer incentives to the public to reduce sugar intake to stop NAFLD at the initial stage

A team of researchers from IIT baths have established bio-chemical relations that underlie between excessive sugar consumption and the development of ‘fatty liver,’ medically known as non-alcoholic fatty liver disease (NAFLD), a statement from the Institute informed.

This study occurred when the Indian government has included NAFD in national programs for cancer prevention and control, diabetes, cardiovascular disease and stroke (NPCDC).

Describing his research, Dr. Procate Mondal, Associate Professor – School of Basic Sciences, IIT Bathing, said, “the molecular mechanism that increases DNL liver because too much sugar is unclear.

“Our goal is to reveal this mechanistic path between consumption of excessive sugar and onset and fatty liver development through de novo lipogenesis (DNL).”

India is the first country in the world to identify the need for actions on NAFLD and for good reasons. The prevalence of NAFLD in India is around nine percent to 32 percent of the population, with the state of Kerala alone has a prevalence of 49 percent and the prevalence of 60 percent surprisingly among school children ally.

One of the causes of NAFLD is consumption of sugar – both table sugar (sucrose) and other forms of carbohydrates. Consumption of excess sugar and carbohydrates causes the liver to turn it into fat in a process called Hepatik DNL, ​​which leads to fat accumulation in the liver.

Through a complementary experimental approach involving mouse models, the IIT bath team has shown a relationship that is until now unknown between the activation of the protein complex caused by carbohydrates called NF-κB and increasing DNL.

“Our data shows that the activation mediated by sugar from the NF-κB P65 that is approachable reduces other protein levels, Sorcin, which, in turn, activates the heart through the bio-chemical line of cascading,” explained the main scientist.

The decomposition of molecular relations between sugar and fat accumulation in the liver is the key to developing therapeutics for this disease. The team has shown that drugs that can inhibit NF-κB can prevent the accumulation of hepat fat caused by sugar. They also showed that Knockdown Sorcin reduced lipid-lowering capabilities from NF-κB inhibitors.

IIT’s findings bathing the team that NF-κB played a key role in lipid accumulation in the heart opening a new way of therapy for NAFLD. NF-κB also plays a role in other diseases involving inflammation, such as cancer, Alzheimer’s disease, atherosclerosis, IBS, strokes, muscle waste and infections, and scientists throughout the world can block NF-κB. Research shows that NAFLD can now be added to the repertoire of diseases that can be treated with drugs that prevent NF-κB.

From a preventive angle, this study convincingly shows that excessive sugar intake leads to a fatty heart. It must offer incentives to the public to reduce sugar intake to stop NAFLD at its initial stage.

The work of the team has been published in the Journal of Biology Chemistry. Research papers have been written together by Dr Mondal, along with their research scholars, Daniel, Surbhi Dogat, Priya Rawat, Abhinav Choubey from IIT bathing, in collaboration with Dr. Mohan Kamthan and Aiysha Siddiq Khan from Jamia Hamdard Institute, New Delhi and Sangam Rajak from Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGI), Lucknow.